Anti-Alpha-1-Trypsin SERPINA1 Antibody Peroxidase Conjugated

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Alpha-1-Trypsin SERPINA1 Antibody Peroxidase Conjugated

catalog :

H00720

quantity :

100 ug

clonality :

polyclonal

host :

domestic goat

conjugate :

HRP

clone name :

polyclonal

reactivity :

human

application :

western blot

product information

SKU :

H00720

Product Name :

Anti-Alpha-1-Trypsin SERPINA1 Antibody Peroxidase Conjugated

Size :

100 ug

Clonality :

Polyclonal

Host :

Goat

Conjugate :

HRP

Reactivity :

Human

Application(s) :

Application Details :

Western Blot, 1:500 - 1:2, 500, human

Description :

Boster Bio Anti-Alpha-1-Trypsin SERPINA1 Antibody Peroxidase Conjugated catalog # H00720. Tested in WB applications. This antibody reacts with Human.

Concentration :

1.0 mg/mL by UV absorbance at 280 nm

Gene Name :

SERPINA1

Uniprot ID :

P01009

Form :

Liquid

Gene Full Name :

Alpha-1-antitrypsin

Synonyms :

Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; Short peptide from AAT; SPAAT; SERPINA1; AAT, PI; PRO0684, PRO2209;

Molecular Weight :

46737 MW

Protein Function :

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

Subcellular Localization :

Secreted. Endoplasmic reticulum. The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.

Tissue Specificity :

Ubiquitous. Expressed in leukocytes and plasma.

Background :

SERPINA1 is also known as PI, A1A or AAT. This gene is mapped to 14q32.1. The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

Research Category :

Apoptosis, Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Intracellular, Kinases, Metabolism, Metabolism Processes, Pathways And Processes, Protease Inhibitors, Proteolysis / Ubiquitin, Response To Hypoxia, Serum Proteins