Mouse Progranulin PicoKine® Quick ELISA Kit | Boster FEK1192 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Progranulin PicoKine® Quick ELISA Kit

catalog :

FEK1192

quantity :

96 wells/kit, with removable strips.

product information

SKU :

FEK1192

Product Name :

Mouse Progranulin PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Mouse Progranulin PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Mouse Grn in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml. Introduction: Boster's PicoKine® Quick ELISA kits features the high sensitivity of PicoKine® ELISA kits and the significantly reduced assay run time. Now you can run the entire ELISA assay in less than 1.5 hours. Compared to regular Picokine ELISA kits, the following sections in the datasheet are different: 1. kit components; 2. preparation before experiment; 3. assay protocol

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Grn

Uniprot ID :

P28798

Immunogen :

Expression system for standard: NS0; Immunogen sequence: T18-L589

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Granulins

Synonyms :

Granulins;PC cell-derived growth factor;PCDGF;Proepithelin;PEPI;Acrogranin;Progranulin;Granulin-1;Granulin-2;Granulin-3;Granulin-4;Granulin-5;Granulin-6;Granulin-7;Grn;

Protein Name :

Granulins

Molecular Weight :

63458 MW

Protein Function :

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Acts as an autocrine growth factor for PC cells.

Subcellular Localization :

Secreted .

Tissue Specificity :

Ubiquitous.

Background :

Granulin, also known as Proepithelin (PEPI) is a protein that in humans is encoded by the GRN gene. This gene is mapped to 17q21.31. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.