Human PLAT/TPA PicoKine® Quick ELISA Kit | Boster FEK0897 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PLAT/TPA PicoKine® Quick ELISA Kit

catalog :

FEK0897

quantity :

96 wells/kit, with removable strips.

price :

499 USD

more info or order :

Boster product webpage

citations: 1

Reference
Tan H, Li L, Zhang W, Ma Z, Zhong X, Li J, et al. Effects of cilnidipine on fibrinolysis in chinese hypertensive patients. Clin Drug Investig. 2005;25:777-83 pubmed

image

image 1 :

Human PLAT/TPA PicoKine ELISA Kit standard curve

product information

SKU :

FEK0897

Product Name :

Human PLAT/TPA PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Price :

499 USD

Description :

Human PLAT/TPA PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Human PLAT in cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine. Sensitivity: 10pg/ml. Introduction: Boster's PicoKine® Quick ELISA kits features the high sensitivity of PicoKine® ELISA kits and the significantly reduced assay run time. Now you can run the entire ELISA assay in less than 1.5 hours. Compared to regular Picokine ELISA kits, the following sections in the datasheet are different: 1. kit components; 2. preparation before experiment; 3. assay protocol

Reactivity :

Human

Application :

ELISA

Gene Name :

PLAT

Uniprot ID :

P00750

Immunogen :

Expression system for standard: CHO; Immunogen sequence: M1-P562

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tissue-type plasminogen activator

Synonyms :

Tissue-type plasminogen activator;t-PA;t-plasminogen activator;tPA;3.4.21.68;Alteplase;Reteplase;Tissue-type plasminogen activator chain A;Tissue-type plasminogen activator chain B;PLAT;

Protein Name :

Tissue-type plasminogen activator

Molecular Weight :

62917 MW

Protein Function :

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Subcellular Localization :

Secreted, extracellular space.

Tissue Specificity :

Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

Sequence Similarities :

Belongs to the peptidase S1 family.

Background :

Plasminogen activator, tissue, also called PLAT or TPA is a serine protease. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This gene was mapped to 8p11.21. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

more info or order :

Boster product webpage