Human TRANCE/RANKL/TNFSF11 PicoKine® Quick ELISA Kit | Boster FEK0842 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TRANCE/RANKL/TNFSF11 PicoKine® Quick ELISA Kit

catalog :

FEK0842

quantity :

96 wells/kit, with removable strips.

product information

SKU :

FEK0842

Product Name :

Human TRANCE/RANKL/TNFSF11 PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Human TRANCE/RANKL/TNFSF11 PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Human TRANCE/RANKL/TNFSF11 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10 pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFSF11

Uniprot ID :

O14788

Immunogen :

Expression system for standard: NS0; Immunogen sequence: G64-D245

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

78 pg/ml - 5,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Background :

Receptor activator of nuclear factor kappa-B ligand(RANKL), also known as tumor necrosis factor ligand superfamily member 11(TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor(TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This gene is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.