Mouse RANK / CD265 PicoKine® Quick ELISA Kit | Boster FEK0830 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse RANK / CD265 PicoKine® Quick ELISA Kit

catalog :

FEK0830

quantity :

96 wells/kit, with removable strips.

product information

SKU :

FEK0830

Product Name :

Mouse RANK / CD265 PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Mouse RANK / CD265 PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Mouse Tnfrsf11a in cell culture supernatants and serum. Sensitivity: 2pg/ml. Introduction: Boster's PicoKine® Quick ELISA kits features the high sensitivity of PicoKine® ELISA kits and the significantly reduced assay run time. Now you can run the entire ELISA assay in less than 1.5 hours. Compared to regular Picokine ELISA kits, the following sections in the datasheet are different: 1. kit components; 2. preparation before experiment; 3. assay protocol

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Tnfrsf11a

Uniprot ID :

O35305

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q30-P213

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 11A

Synonyms :

Tumor necrosis factor receptor superfamily member 11A;Osteoclast differentiation factor receptor;ODFR;Receptor activator of NF-KB;CD265;Tnfrsf11a;Rank;

Protein Name :

Tumor necrosis factor receptor superfamily member 11A

Molecular Weight :

66621 MW

Protein Function :

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.

Background :

Receptor Activator of Nuclear Factor kappa B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain (residues 234-616), which contain three putative TRAF-binding domains (termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK.