Human BAFF/TNFSF13B PicoKine® Quick ELISA Kit | Boster FEK0663 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human BAFF/TNFSF13B PicoKine® Quick ELISA Kit

catalog :

FEK0663

quantity :

96 wells/kit, with removable strips.

product information

SKU :

FEK0663

Product Name :

Human BAFF/TNFSF13B PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Human BAFF/TNFSF13B PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Human BAFF/TNFSF13B in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 2 pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFSF13B

Uniprot ID :

Q9Y275

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A134-L285

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Background :

BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. BAFF was localized in astrocytes close to BAFF-R-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system(CNS) lymphomas.1 The TNF superfamily member B cell-activating factor(BAFF) plays an important role in humoral immunity and in autoimmune diseases, including RA.Local BAFF gene targeting inhibited proinflammatory cytokine expression, suppressed generation of plasma cells and Th17 cells, and markedly ameliorated joint pathology.2 The B cell activating factor BAFF(BlyS/TALL-1/zTNF4) is a tumor necrosis factor(TNF)-related ligand that promotes B cell survival and binds to three receptors(BCMA, TACI, and the recently described BAFF-R).3 Human BAFF was mapped to chromosome 13q32-34.4 The standard used in this kit is recombinant soluble human BAFF(A134-L295) with the molecular mass of 19.6KDa.