Mouse Gp130/IL6ST PicoKine® Quick ELISA Kit | Boster FEK0577 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Gp130/IL6ST PicoKine® Quick ELISA Kit

catalog :

FEK0577

quantity :

96 wells/kit, with removable strips.

product information

SKU :

FEK0577

Product Name :

Mouse Gp130/IL6ST PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Mouse Gp130/IL6ST PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Mouse Il6st in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml. Introduction: Boster's PicoKine® Quick ELISA kits features the high sensitivity of PicoKine® ELISA kits and the significantly reduced assay run time. Now you can run the entire ELISA assay in less than 1.5 hours. Compared to regular Picokine ELISA kits, the following sections in the datasheet are different: 1. kit components; 2. preparation before experiment; 3. assay protocol

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Il6st

Uniprot ID :

Q00560

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q23-E617

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-6 receptor subunit beta

Synonyms :

Interleukin-6 receptor subunit beta;IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB;Interleukin-6 signal transducer;Membrane glycoprotein 130;gp130;Oncostatin-M receptor subunit alpha;CD130;Il6st;

Protein Name :

Interleukin-6 receptor subunit beta

Molecular Weight :

102451 MW

Protein Function :

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver. Found in all the cell lines tested except BaF-B03. Expression not restricted to IL6-responsive cells.

Sequence Similarities :

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Background :

GP130 (Glycoprotein 130) also known as IL6ST or CD130, is a transmembrane protein which is the founding member of the class of all cytokine receptors. The GP130 gene is mapped on 5q11.2. Gp130 showed an apparent molecular mass of 130 kD by SDS-PAGE. Gp130 is involved in the formation of high-affinity IL6-binding sites and in IL6 signal transduction. Sgp130 has a role in modulating signals transduced by membrane-bound gp130. Gp130 is an important part of many different types of signaling complexes.Gp130 molecules with mutations in either of these segments could not transduce a growth signal.