Human CD40 Ligand/TNFSF5/CD40LG PicoKine® Quick ELISA Kit

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CD40 Ligand/TNFSF5/CD40LG PicoKine® Quick ELISA Kit

catalog :

FEK0573

quantity :

96 wells/kit, with removable strips.

product information

SKU :

FEK0573

Product Name :

Human CD40 Ligand/TNFSF5/CD40LG PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Human CD40 Ligand/TNFSF5/CD40LG PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Human CD40 Ligand/TNFSF5/CD40LG in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15 pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CD40LG

Uniprot ID :

P29965

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: E108-L261

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Background :

CD40 ligand(CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb/IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells.CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.