Mouse OPG (TNFRSF11B) / Osteoprotegerin PicoKine® Quick ELISA Kit

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse OPG (TNFRSF11B) / Osteoprotegerin PicoKine® Quick ELISA Kit

catalog :

FEK0481

quantity :

96 wells/kit, with removable strips.

price :

499 USD

more info or order :

Boster product webpage

citations: 1

Reference
Hartwich J, Orr W, Ng C, Spence Y, McLaughlin J, Furman W, et al. Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model. J Pediatr Surg. 2013;48:47-55 pubmed publisher

image

image 1 :

Mouse OPG (TNFRSF11B) PicoKine ELISA Kit standard curve

product information

SKU :

FEK0481

Product Name :

Mouse OPG (TNFRSF11B) / Osteoprotegerin PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Price :

499 USD

Description :

Mouse OPG (TNFRSF11B) / Osteoprotegerin PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Mouse Tnfrsf11b in cell culture supernatants, serum and plasma (EDTA). Sensitivity: 5pg/ml. Introduction: Boster's PicoKine® Quick ELISA kits features the high sensitivity of PicoKine® ELISA kits and the significantly reduced assay run time. Now you can run the entire ELISA assay in less than 1.5 hours. Compared to regular Picokine ELISA kits, the following sections in the datasheet are different: 1. kit components; 2. preparation before experiment; 3. assay protocol

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Tnfrsf11b

Uniprot ID :

O08712

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E22-L401

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.7 pg/ml - 6,000 pg/ml

Sensitivity :

<5 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 11B

Synonyms :

Tumor necrosis factor receptor superfamily member 11B;Osteoclastogenesis inhibitory factor;Osteoprotegerin;Tnfrsf11b;Ocif, Opg;

Protein Name :

Tumor necrosis factor receptor superfamily member 11B

Molecular Weight :

45923 MW

Protein Function :

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Subcellular Localization :

Secreted.

Tissue Specificity :

Highly expressed in liver, lung, stomach, intestines and calvaria. Highly expressed in decidua and placenta, and in embryo.

Sequence Similarities :

Contains 2 death domains.

Background :

Osteoprotegerin (OPG) is identical to osteoclastogenesis inhibitory factor (OCIF), a soluble member of the tumor-necrosis factor receptor family that inhibits osteoclastogenesis. OPG is considered to play an important role in the regulation of bone resorption by modifying osteoclast differentiation. Osteoprotegerin is an independent risk factor for the progression of atherosclerosis and onset of cardiovascular disease. It can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity. OPG system may play a critical role in the development of osteolytic bone disease in multiple myeloma and that targeting this system may have therapeutic potential. OPG also plays a role in the vascular system.

more info or order :

Boster product webpage