Human EGFR PicoKine® Quick ELISA Kit | Boster FEK0327 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human EGFR PicoKine® Quick ELISA Kit

catalog :

FEK0327

quantity :

96 wells/kit, with removable strips.

product information

SKU :

FEK0327

Product Name :

Human EGFR PicoKine® Quick ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Human EGFR PicoKine® Quick ELISA Kit (90 minutes, 96 Tests). Quantitate Human EGFR in cell culture supernatants, serum, plasma (heparin, EDTA) and human milk. Sensitivity: 1 pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

EGFR

Uniprot ID :

P00533

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M1-S645

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and human milk

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Background :

The epidermal growth factor receptor(EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family(EGF-family) of extracellular protein ligands.1 It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR(ErbB-1), HER2/c-neu(ErbB-2), Her 3(ErbB-3) and Her 4(ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha(TGFalpha). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR overexpression(known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.