Anti-human CD10 Antibody Unconjugated, Flow Validated | Boster FC04065 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-human CD10 Antibody Unconjugated, Flow Validated

catalog :

FC04065

quantity :

100Âµg, 500Âµg

price :

108; 432 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

FR4D11

reactivity :

human

application :

flow cytometry

product information

sku :

FC04065

name :

Anti-human CD10 Antibody Unconjugated, Flow Validated

price :

108; 432 USD

immunogen :

Raji cells

form :

Liquid

host :

Mouse

contents :

PBS, pH7.2, 0.09% NaN3

purification :

Protein A purified

clonality :

Monoclonal

description :

Mouse Monoclonal Anti-human CD10 Unconjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells.

size :

100Âµg, 500Âµg

reactivity :

Human

applications :

Flow Cytometry

background :

CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase(NEP), Neprilysin, or common acute lymphoblastic leukemia antigen(CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.

clone number :

FR4D11

gene full name :

Neprilysin

gene name :

MME

isotype :

IgG1,k

protein function :

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

protein name :

Neprilysin

storage :

4 . Do not freeze.

subcellular localization :

Cell membrane; Single-pass type II membrane protein.

synonyms :

Neprilysin;3.4.24.11 ;Atriopeptidase;Common acute lymphocytic leukemia antigen;CALLA;Enkephalinase;Neutral endopeptidase 24.11;NEP;Neutral endopeptidase;Skin fibroblast elastase;SFE;CD10;MME;EPN;

uniprot id :

P08473