Anti-Human CD31 PECAM1 Monoclonal Antibody Unconjugated Conjugated, Flow Validated

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Human CD31 PECAM1 Monoclonal Antibody Unconjugated Conjugated, Flow Validated

catalog :

FC01513

quantity :

100 ug, 500 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

JC70

The same clone is also sold as:

Abnova: MAB10765
Santa Cruz Biotechnology: sc-53411
BioLegend: 623552, 623551
OriGene: TA327635

reactivity :

human

application :

flow cytometry

product information

SKU :

FC01513

Product Name :

Anti-Human CD31 PECAM1 Monoclonal Antibody Unconjugated Conjugated, Flow Validated

Size :

100 ug, 500 ug

Clonality :

Monoclonal

Clone Number :

JC70

Host :

Mouse

Reactivity :

Human

Application(s) :

Flow Cytometry

Application Details :

Flow Cytometry

Description :

Boster Bio Anti-Human CD31 PECAM1 Monoclonal Antibody Unconjugated Conjugated, Flow Validated catalog # FC01513. Tested in Flow Cytometry applications. This antibody reacts with Human.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

PECAM1

Uniprot ID :

P16284

Immunogen :

Cell membrane preparation from the spleen of a patient with hairy cell leukaemia

Form :

Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

Contents :

PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

Purification :

Affinity column chromatography

Gene Full Name :

Platelet endothelial cell adhesion molecule

Synonyms :

Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31; PECAM1;

Molecular Weight :

82536 MW

Protein Function :

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock- induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.

Tissue Specificity :

Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).

Research Category :

Angiogenesis, Cardiovascular, Cell Adhesion, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton / Ecm, Immunology, Signal Transduction