Anti-human CD117 Antibody Unconjugated, Flow Validated | Boster FC01335 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-human CD117 Antibody Unconjugated, Flow Validated

catalog :

FC01335

quantity :

100Âµg, 500Âµg

price :

195; 375 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BA7.3C.9

reactivity :

human

application :

flow cytometry

product information

sku :

FC01335

name :

Anti-human CD117 Antibody Unconjugated, Flow Validated

price :

195; 375 USD

immunogen :

Human erythroleukemia cell line OCIM1

form :

Liquid

host :

Mouse

contents :

PBS, pH7.2, 0.09% NaN3

purification :

Protein A purified

clonality :

Monoclonal

description :

Mouse Monoclonal Anti-human CD117 Unconjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells.

size :

100Âµg, 500Âµg

reactivity :

Human

applications :

Flow Cytometry

background :

SCFR(Mast/stem cell growth factor receptor), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a protein that in humans is encoded by the KIT gene. KIT was first described as the cellular homolog of the feline sarcoma viral oncogene v-kit. The KIT gene is mapped on 4q12. Kit was expressed on the surface of germ cells up to the pachytene stage. Signaling from the KIT receptor tyrosine kinase is essential for primordial germ cell growth both in vivo and in vitro. Determination of the KIT effectors acting in primordial germ cells has been hampered by the lack of effective methods to manipulate easily gene expression in these cells.

clone number :

BA7.3C.9

gene full name :

Mast/stem cell growth factor receptor Kit

gene name :

KIT

isotype :

IgG2a,k

protein function :

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

protein name :

Mast/stem cell growth factor receptor Kit

research category :

immunology cell type markers cytokines tags & cell markers tumor associated signal transduction protein phosphorylation tyrosine kinases receptor tyrosine kinases neuroscience neurotransmission receptors / channels tyrosine kinase receptors stem cells germline stem cells embryonic germ cells hematopoietic progenitors surface molecules cancer oncoproteins/suppressors oncoproteins growth factor receptors myeloid mast cell lineage hematopoietic stem cells hsc markers developmental biology reproduction germ cell markers organogenesis hematopoietic system development

storage :

4 . Do not freeze.

subcellular localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

synonyms :

Mast/stem cell growth factor receptor Kit;SCFR;2.7.10.1;Piebald trait protein;PBT;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;p145 c-kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;CD117;KIT;SCFR;

tissue specificity :

Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells.

uniprot id :

P10721