Anti-human CD71 Antibody Unconjugated, Flow Validated | Boster FC00591 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-human CD71 Antibody Unconjugated, Flow Validated

catalog :

FC00591

quantity :

100Âµg, 500Âµg

price :

129; 516 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OKT9

reactivity :

human

application :

flow cytometry

product information

sku :

FC00591

name :

Anti-human CD71 Antibody Unconjugated, Flow Validated

price :

129; 516 USD

immunogen :

Human acute lymphoblastic leukemia cells

form :

Liquid

host :

Mouse

contents :

PBS, pH7.2, 0.09% NaN3

purification :

Protein A purified

clonality :

Monoclonal

description :

Mouse Monoclonal Anti-human CD71 Unconjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells.

size :

100Âµg, 500Âµg

reactivity :

Human

applications :

Flow Cytometry

background :

CD71 is also known as transferrin receptor(TFRC). Nikinmaa and Schroder(1987) concluded that p90 and TFRC are the same protein: studies using monoclonal antibodies indicated that exhaustive precipitation of radioactively labeled lysates with one antibody removed all activity of lysates with the other. Peptide maps of antigens recognized with both antibodies showed great similarity and indicated that both antibodies react with the same antigen, the human transferrin receptor, but with different antigenic sites of the molecule.TFR is assigned to chromosome 3.

clone number :

OKT9

gene full name :

Transferrin receptor protein 1

gene name :

TFRC

isotype :

IgG1,k

protein function :

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

protein name :

Transferrin receptor protein 1

research category :

cardiovascular blood serum proteins immunology cell type markers non-lineage stem cells neural stem cells surface molecules hematopoietic progenitors lymphoid b lymphocytic lineage t lymphocytic lineage myeloid erythrocytic lineage cancer cancer metabolism response to hypoxia metabolism pathways and processes metabolism processes types of disease

storage :

4 . Do not freeze.

subcellular localization :

Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

synonyms :

Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;T9;p90;CD71;Transferrin receptor protein 1, serum form;sTfR;TFRC;

uniprot id :

P02786