Anti-human CD45 Antibody Unconjugated, Flow Validated | Boster FC00555 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-human CD45 Antibody Unconjugated, Flow Validated

catalog :

FC00555

quantity :

100Âµg, 500Âµg

price :

79; 320 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

F10-89-4

reactivity :

human

application :

flow cytometry

product information

sku :

FC00555

name :

Anti-human CD45 Antibody Unconjugated, Flow Validated

price :

79; 320 USD

immunogen :

Human T lymphocytes

form :

Liquid

host :

Mouse

contents :

PBS, pH7.2, 0.09% NaN3

purification :

Protein A purified

clonality :

Monoclonal

description :

Mouse Monoclonal Anti-human CD45 Unconjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells.

size :

100Âµg, 500Âµg

reactivity :

Human

applications :

Flow Cytometry

background :

CD45(Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase(PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase(PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse(IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.

clone number :

F10-89-4

gene full name :

Receptor-type tyrosine-protein phosphatase C

gene name :

PTPRC

isotype :

IgG2a,k

protein function :

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

protein name :

Receptor-type tyrosine-protein phosphatase C

research category :

signal transduction protein phosphorylation tyrosine phosphatases signal transduction adapters transmembrane

storage :

4 . Do not freeze.

subcellular localization :

Membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts.

synonyms :

Receptor-type tyrosine-protein phosphatase C;3.1.3.48;Leukocyte common antigen;L-CA;T200;CD45;PTPRC;CD45;

uniprot id :

P08575