Human TAFI/CPB2 ELISA Kit EZ-Set™ (DIY Antibody Pairs)

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TAFI/CPB2 ELISA Kit EZ-Set™ (DIY Antibody Pairs)

catalog :

EZ1502

quantity :

For 5 plates, 96 wells each

product information

SKU :

EZ1502

Product Name :

Human TAFI/CPB2 ELISA Kit EZ-Set™ (DIY Antibody Pairs)

Size :

For 5 plates, 96 wells each

Description :

Human TAFI/CPB2 ELISA Kit EZ-Set™ (DIY Antibody Pairs) (antibody pairs and standards for assay development). Quantitate Human CPB2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 15 pg/ml. Product Features: Your ideal low cost ELISA solution. EZ Set™ ELISA kit contains the necessary core reagents develop and run the ELISA, including ELISA-optimized matched antibody pairs, recombinant protein standards, and HRP conjugated Avidin-Biotin-Complex (ABC). One kit is sufficient for developing 5 plates (96 well format). EZ Set™ ELISAs are ideal for experienced ELISA users on a budget and great for exploratory work--a fast and easy way to identify the relevant protein targets of interest/relevance to your studies.

Reactivity :

Human

Application :

ELISA

Gene Name :

CPB2

Uniprot ID :

Q96IY4

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M1-V423

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Carboxypeptidase B2

Synonyms :

Carboxypeptidase B2;3.4.17.20 ;Carboxypeptidase U;CPU;Plasma carboxypeptidase B;pCPB;Thrombin-activable fibrinolysis inhibitor;TAFI;CPB2;

Protein Name :

Carboxypeptidase B2

Molecular Weight :

48424 MW

Protein Function :

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

Subcellular Localization :

Secreted.

Tissue Specificity :

Plasma; synthesized in the liver.

Background :

Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Research Category :

Amino Acid Metabolism, Amino Acids, Atherosclerosis, Cardiovascular, Heart Disease, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Serum Proteins, Signal Transduction