iNOS Colorimetric Cell-Based ELISA Kit | Boster EKC1302 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

iNOS Colorimetric Cell-Based ELISA Kit

catalog :

EKC1302

quantity :

1 kit, containing 1 plates and all necessary reagents

product information

SKU :

EKC1302

Product Name :

iNOS Colorimetric Cell-Based ELISA Kit

Size :

1 kit, containing 1 plates and all necessary reagents

Description :

The iNOS Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor iNOS protein expression profile in cells. The kit can be used for measuring the relative amounts of iNOS in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on iNOS.

Reactivity :

Human

Application :

ELISA

Gene Name :

NOS2

Uniprot ID :

P35228

Assay Range :

> 5000 Cells

Sensitivity :

>5000 cells

Storage :

4°C/6 Months

Gene Full Name :

Nitric oxide synthase, inducible

Synonyms :

Nitric oxide synthase, inducible;1.14.13.39;Hepatocyte NOS;HEP-NOS;Inducible NO synthase;Inducible NOS;iNOS;N

Molecular Weight :

131117 MW

Protein Function :

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).

Tissue Specificity :

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.