Human PRELP/Prolargin ELISA Kit PicoKine® | Boster EK2110 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PRELP/Prolargin ELISA Kit PicoKine®

catalog :

EK2110

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2110

Product Name :

Human PRELP/Prolargin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PRELP ELISA Kit PicoKine® (96 Tests). Quantitate Human PRELP in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PRELP

Uniprot ID :

P51888

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q21-I382

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.8 pg/ml - 6,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated monoclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

proline and arginine rich end leucine rich repeat protein

Synonyms :

Prolargin; Proline-arginine-rich end leucine-rich repeat protein; PRELP; SLRR2A

Protein Function :

May anchor basement membranes to the underlying connective tissue.

Subcellular Localization :

extracellular matrix

Tissue Specificity :

Connective tissue

Background :

Prolargin is a protein that in humans is encoded by the PRELP gene. It is mapped to 1q32.1. The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.