Human PTH1R ELISA Kit PicoKine® | Boster EK2087 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PTH1R ELISA Kit PicoKine®

catalog :

EK2087

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2087

Product Name :

Human PTH1R ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PTH1R ELISA Kit PicoKine® (96 Tests). Quantitate Human PTH1R in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PTH1R

Uniprot ID :

Q03431

Immunogen :

Expression system for standard: CHO; Immunogen sequence: Y23-M189

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

parathyroid hormone 1 receptor

Synonyms :

Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor; PTH1R; PTHR; PTHR1

Protein Function :

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Subcellular Localization :

Cell membrane. Multi-pass membrane protein.

Tissue Specificity :

Expressed in most tissues. Most abundant in kidney, bone and liver.

Background :

Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as parathyroid hormone 1 receptor (PTH1R), is a protein that in humans is encoded by the PTH1R gene. It is mapped to 3p21.31. The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.