Human IL-17RD ELISA Kit PicoKine® | Boster EK2083 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-17RD ELISA Kit PicoKine®

catalog :

EK2083

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2083

Product Name :

Human IL-17RD ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL-17RD ELISA Kit PicoKine® (96 Tests). Quantitate Human IL17RD in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL17RD

Uniprot ID :

Q8NFM7

Immunogen :

Expression system for standard: NS0; Immunogen sequence: C17-R299

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

interleukin 17 receptor D

Synonyms :

Interleukin-17 receptor D; IL-17 receptor D; IL-17RD; IL17Rhom; Interleukin-17 receptor-like protein; Sef homolog; hSef; IL17RD; IL17RLM; SEF; UNQ6115; PRO20026

Protein Function :

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons.

Subcellular Localization :

Cell membrane. Single-pass type I membrane protein. Golgi apparatus membrane. Cytoplasm.

Tissue Specificity :

Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells.

Background :

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene. It is mapped to 3p14.3. This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms.