Human FGFRL1 ELISA Kit PicoKine® | Boster EK2079 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human FGFRL1 ELISA Kit PicoKine®

catalog :

EK2079

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2079

Product Name :

Human FGFRL1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human FGFRL1 ELISA Kit PicoKine® (96 Tests). Quantitate Human FGFRL1 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

FGFRL1

Uniprot ID :

Q8N441

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A25-P378

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

fibroblast growth factor receptor like 1

Synonyms :

Fibroblast growth factor receptor-like 1; FGF receptor-like protein 1; FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5; FGFRL1; FGFR5, FHFR; UNQ480; PRO943

Protein Function :

Has a negative effect on cell proliferation.

Subcellular Localization :

Membrane. Single-pass type I membrane protein.

Tissue Specificity :

Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.

Background :

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. It is mapped to 4p16.3. The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.