Human ARSB/Arylsulfatase B ELISA Kit PicoKine® | Boster EK2078 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ARSB/Arylsulfatase B ELISA Kit PicoKine®

catalog :

EK2078

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2078

Product Name :

Human ARSB/Arylsulfatase B ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ARSB ELISA Kit PicoKine® (96 Tests). Quantitate Human ARSB in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ARSB

Uniprot ID :

P15848

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S37-M533

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

arylsulfatase B

Synonyms :

Arylsulfatase B; ASB; N-acetylgalactosamine-4-sulfatase; G4S; ARSB

Protein Function :

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels.

Subcellular Localization :

Lysosome. Cell surface.

Background :

Arylsulfatase B is an enzyme associated with mucopolysaccharidosis VI. It is mapped to 5q14.1. Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.