Human GFRA3 ELISA Kit PicoKine® | Boster EK2075 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human GFRA3 ELISA Kit PicoKine®

catalog :

EK2075

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2075

Product Name :

Human GFRA3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human GFRA3 ELISA Kit PicoKine® (96 Tests). Quantitate Human GFRA3 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

GFRA3

Uniprot ID :

O60609

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D32-N374

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

GDNF family receptor alpha 3

Synonyms :

GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3; GFRA3; UNQ339; PRO538; PRO3664

Protein Function :

Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.

Subcellular Localization :

Cell membrane. GPI-anchor.

Tissue Specificity :

Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.

Background :

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene. It is mapped to 5q31.2. The protein encoded by this gene is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.