Human GFRA2 ELISA Kit PicoKine® | Boster EK2072 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human GFRA2 ELISA Kit PicoKine®

catalog :

EK2072

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2072

Product Name :

Human GFRA2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human GFRA2 ELISA Kit PicoKine® (96 Tests). Quantitate Human GFRA2 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

GFRA2

Uniprot ID :

O00451

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S22-S444

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

GDNF family receptor alpha 2

Synonyms :

GDNF family receptor alpha-2; GDNF receptor alpha-2; GDNFR-alpha-2; GFR-alpha-2; GDNF receptor beta; GDNFR-beta; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2; GFRA2; GDNFRB; RETL2; TRNR2

Protein Function :

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.

Subcellular Localization :

Cell membrane. GPI-anchor.

Tissue Specificity :

Found in both brain and placenta.

Background :

GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene. It is mapped to 8p21.3. The GFRA2 protein is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. They both bind the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. GFRA2 (gene) has been shown to interact with GDNF.