Human GFRA1 ELISA Kit PicoKine® | Boster EK2069 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human GFRA1 ELISA Kit PicoKine®

catalog :

EK2069

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2069

Product Name :

Human GFRA1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human GFRA1 ELISA Kit PicoKine® (96 Tests). Quantitate Human GFRA1 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

GFRA1

Uniprot ID :

P56159

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D25-S429

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

GDNF family receptor alpha 1

Synonyms :

GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GFRA1; GDNFRA; RETL1; TRNR1

Protein Function :

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

Subcellular Localization :

Cell membrane. GPI-anchor.

Background :

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to 10q25.3. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.