Human DCR2/TNFRSF10D ELISA Kit PicoKine® | Boster EK2067 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human DCR2/TNFRSF10D ELISA Kit PicoKine®

catalog :

EK2067

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2067

Product Name :

Human DCR2/TNFRSF10D ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human DCR2/TNFRSF10D ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF10D in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF10D

Uniprot ID :

Q9UBN6

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A56-H211

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

TNF receptor superfamily member 10d

Synonyms :

Tumor necrosis factor receptor superfamily member 10D; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD264; TNFRSF10D; DCR2, TRAILR4, TRUNDD; UNQ251; PRO288

Protein Function :

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway.

Subcellular Localization :

Membrane. Single-pass type I membrane protein.

Tissue Specificity :

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Background :

Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily. It is mapped to 8p21.3. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.