Human PLA2G4A ELISA Kit PicoKine® | Boster EK2065 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PLA2G4A ELISA Kit PicoKine®

catalog :

EK2065

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2065

Product Name :

Human PLA2G4A ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PLA2G4A ELISA Kit PicoKine® (96 Tests). Quantitate Human PLA2G4A in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PLA2G4A

Uniprot ID :

P47712

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M1-A749

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

phospholipase A2 group IVA

Synonyms :

Cytosolic phospholipase A2; Cpla2; Phospholipase A2 group IVA; Phospholipase A2; Phosphatidylcholine 2-acylhydrolase; Lysophospholipase; PLA2G4A; CPLA2; PLA2G4

Protein Function :

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Subcellular Localization :

Cytoplasm. Cytoplasmic vesicle.

Tissue Specificity :

Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.

Background :

Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. It is mapped to 1q31.1. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.