Mouse CLEC4F ELISA Kit PicoKine® | Boster EK2047 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse CLEC4F ELISA Kit PicoKine®

catalog :

EK2047

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2047

Product Name :

Mouse CLEC4F ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse CLEC4F ELISA Kit PicoKine® (96 Tests). Quantitate Mouse CLEC4F in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CLEC4F

Uniprot ID :

Q8N1N0

Immunogen :

Expression system for standard: NS0; Immunogen sequence: R70-G548

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

625 pg/ml - 40,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

a monoclonal antibody from rat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-type lectin domain family 4, member f

Synonyms :

C-type lectin domain family 4 member F; C-type lectin superfamily member 13; C-type lectin 13; CLEC4F; CLECSF13

Protein Function :

Receptor with an affinity for galactose and fucose. Could be involved in endocytosis.

Subcellular Localization :

Membrane. Single-pass type II membrane protein.

Background :

C-type lectin domain family 4 member F is a protein that in humans is encoded by the CLEC4F gene. This gene is mapped to 6; 6 C3. CLEC4F is an 80 kDa, type II transmembrane glycoprotein member of the C-type lectin superfamily. Mature mouse CLEC4F consists of a 42 amino acid (aa) cytoplasmic domain, a 27 aa transmembrane segment, and a 479 aa extracellular domain that contains an extended stalk region plus one carbohydrate recognition domain. Within the ECD, mouse CLEC4F shares 48% and 79% aa sequence identity with human and rat CLEC4F, respectively. The stalk region of CLEC4F is a coiled coil domain that mediates homotrimer formation. CLEC4F is expressed on Kupffer cells in the liver, but not on macrophages in other tissues. CLEC4F preferentially binds galactose and N‑acetylgalactosamine in a calcium-dependent manner. Its activity at neutral, but not at acidic pH, suggests a capacity to internalize and release ligands into the endosomal system.