Human SMPD1 ELISA Kit PicoKine® | Boster EK2025 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human SMPD1 ELISA Kit PicoKine®

catalog :

EK2025

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2025

Product Name :

Human SMPD1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human SMPD1 ELISA Kit PicoKine® (96 Tests). Quantitate Human SMPD1 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SMPD1

Uniprot ID :

P17405

Immunogen :

Expression system for standard: CHO; Immunogen sequence: L47-C631

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

sphingomyelin phosphodiesterase 1

Synonyms :

Sphingomyelin phosphodiesterase; Acid sphingomyelinase; aSMase; SMPD1; ASM

Protein Name :

Sphingomyelin phosphodiesterase

Protein Function :

Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.

Subcellular Localization :

Secreted. Lysosome.

Background :

Sphingomyelin phosphodiesterase 1 (SMPD1), also known as acid sphingomyelinase (ASM), is an enzyme that in humans is encoded by the SMPD1 gene. This gene is mapped to 11p15.4. The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. Sphingomyelin phosphodiesterase 1 belongs to the sphingomyelin phosphodiesterase family.

Research Category :

Apoptosis, Associated Proteins, Cancer, Cell Biology, Intracellular, Lipid Metabolism, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Signal Transduction