Human Osteoadherin/OSAD/OMD ELISA Kit PicoKine® | Boster EK2017 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Osteoadherin/OSAD/OMD ELISA Kit PicoKine®

catalog :

EK2017

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK2017

Product Name :

Human Osteoadherin/OSAD/OMD ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Osteoadherin ELISA Kit PicoKine® (96 Tests). Quantitate Human OMD in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

OMD

Uniprot ID :

Q99983

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q21-E421

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

osteomodulin

Synonyms :

Osteomodulin; Keratan sulfate proteoglycan osteomodulin; KSPG osteomodulin; Osteoadherin; OSAD; OMD; SLRR2C; UNQ190; PRO216

Protein Name :

Osteomodulin

Protein Function :

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha (V)beta3-integrin.

Subcellular Localization :

Extracellular matrix

Tissue Specificity :

Bone specific.

Background :

Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is encoded by the OMD gene. This gene is mapped to 9q22.31. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). LRR motifs consist of approximately 20‑30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta -sheet and one alpha -helix. Human OSAD is expressed as an even larger 110 kDa molecule in teeth. OSAD contains eight sulfated tyrosine residues and is distinguished from other class II SLRPs by the presence of an approximately 70 aa C‑terminal acidic domain. OSAD is expressed by fetal and adult osteoblasts but is not detectable in cartilage or tendon. In dental tissue, OSAD is expressed by odontoblasts and ameloblasts and is involved in the mineralization of bone and teeth. OSAD promotes the adhesion of osteoblasts and odontoblasts to the surrounding matrix, an interaction that is mediated by Integrin alpha V beta 3.

Research Category :

Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Signal Transduction, Structures