Human Cystatin M/Cystatin E/CST6 ELISA Kit PicoKine® | Boster EK1965 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Cystatin M/Cystatin E/CST6 ELISA Kit PicoKine®

catalog :

EK1965

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1965

Product Name :

Human Cystatin M/Cystatin E/CST6 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Cystatin M/CST6 ELISA Kit PicoKine® (96 Tests). Quantitate Human CST6 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CST6

Uniprot ID :

Q15828

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: R29-M149

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

cystatin E/M

Synonyms :

Cystatin-M; Cystatin-6; Cystatin-E; CST6

Protein Function :

Shows moderate inhibition of cathepsin B but is not active against cathepsin C.

Subcellular Localization :

Secreted.

Tissue Specificity :

Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.

Background :

Cystatin-M is a protein that in humans is encoded by the CST6 gene. It is mapped to 11q13.1. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Research Category :

Cell Biology, Protease Inhibitors, Proteolysis / Ubiquitin