Human Cystatin D/CST5 ELISA Kit PicoKine® | Boster EK1964 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Cystatin D/CST5 ELISA Kit PicoKine®

catalog :

EK1964

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1964

Product Name :

Human Cystatin D/CST5 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Cystatin D/CST5 ELISA Kit PicoKine® (96 Tests). Quantitate Human CST5 in cell culture supernatants, serum and plasma (heparin, EDTA) , saliva and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CST5

Uniprot ID :

P28325

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: G21-V142

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA), saliva and urine

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

cystatin D

Synonyms :

Cystatin-D; Cystatin-5; CST5

Protein Function :

Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in submandibular and sublingual saliva but not in parotid saliva. Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall bladder tissue.

Background :

Cystatin-D is a protein that in humans is encoded by the CST5 gene. It is mapped to 20p11.21. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity.

Research Category :

Proteolysis / Ubiquitin