Human Nectin-3/CD113 ELISA Kit PicoKine® | Boster EK1961 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Nectin-3/CD113 ELISA Kit PicoKine®

catalog :

EK1961

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1961

Product Name :

Human Nectin-3/CD113 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Nectin-3/CD113 ELISA Kit PicoKine® (96 Tests). Quantitate Human NECTIN3 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

NECTIN3

Uniprot ID :

Q9NQS3

Immunogen :

Expression system for standard: NS0; Immunogen sequence: G58-T404

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

nectin cell adhesion molecule 3

Synonyms :

Nectin-3; CDw113; Nectin cell adhesion molecule 3; Poliovirus receptor-related protein 3; CD113; NECTIN3; PRR3; PVRL3

Protein Function :

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Subcellular Localization :

Cell membrane, Single-pass membrane protein, Postsynaptic cell membrane

Tissue Specificity :

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Background :

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. It is mapped to 19q13.32. This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants.

Research Category :

Host Virus Interaction, Immunoglobulins, Immunology, Interspecies Interaction, Microbiology, Receptors