Human Nectin-2/CD112 ELISA Kit PicoKine® | Boster EK1960 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Nectin-2/CD112 ELISA Kit PicoKine®

catalog :

EK1960

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1960

Product Name :

Human Nectin-2/CD112 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Nectin-2/CD112 ELISA Kit PicoKine® (96 Tests). Quantitate Human NECTIN2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 0.1ng/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

NECTIN2

Uniprot ID :

Q92692

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q32-G360

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<0.1 ng/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

nectin cell adhesion molecule 2

Synonyms :

Nectin-2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2; CD112; NECTIN2; HVEB; PRR2; PVRL2

Protein Function :

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Subcellular Localization :

Cell membrane, Single-pass type I membrane protein

Tissue Specificity :

Ubiquitous.

Background :

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein. It is mapped to 19q13.32. This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Research Category :

Host Virus Interaction, Immunoglobulins, Immunology, Interspecies Interaction, Microbiology, Receptors