Human CHRDL1 ELISA Kit PicoKine® | Boster EK1953 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CHRDL1 ELISA Kit PicoKine®

catalog :

EK1953

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1953

Product Name :

Human CHRDL1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CHRDL1 ELISA Kit PicoKine® (96 Tests). Quantitate Human CHRDL1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CHRDL1

Uniprot ID :

Q9BU40

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E22-C450

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.6 pg/ml - 6,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

chordin like 1

Synonyms :

Chordin-like protein 1; Neuralin-1; Neurogenesin-1; Ventroptin; CHRDL1; NRLN1

Protein Function :

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.

Subcellular Localization :

Secreted

Tissue Specificity :

Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.

Background :

Chordin-like 1 is a protein that in humans is encoded by the CHRDL1 gene. It is mapped to Xq23. This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.

Research Category :

Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Stem Cells