Human PLA2G2A ELISA Kit PicoKine® | Boster EK1944 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PLA2G2A ELISA Kit PicoKine®

catalog :

EK1944

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1944

Product Name :

Human PLA2G2A ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PLA2G2A ELISA Kit PicoKine® (96 Tests). Quantitate Human PLA2G2A in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PLA2G2A

Uniprot ID :

P14555

Immunogen :

Expression system for standard: NS0; Immunogen sequence: N21-C144

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

phospholipase A2 group IIA

Synonyms :

Phospholipase A2, membrane associated; GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; PLA2G2A; PLA2B; PLA2L; RASF-A

Protein Function :

Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site which is distinct from the classical ligand-binding site and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner.

Subcellular Localization :

Secreted, Cell membrane, Peripheral membrane protein

Background :

Phospholipase A2, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene. It is mapped to 1p36.13. The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5'UTRs have been found for this gene.

Research Category :

Cancer, Cardiovascular, Lipases, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Lipid Signaling, Lipids / Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Signal Transduction, Signaling Pathway