Human CA12/Carbonic anhydrase 12 ELISA Kit PicoKine® | Boster EK1942 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CA12/Carbonic anhydrase 12 ELISA Kit PicoKine®

catalog :

EK1942

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1942

Product Name :

Human CA12/Carbonic anhydrase 12 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CA12 ELISA Kit PicoKine® (96 Tests). Quantitate Human CA12 in cell culture supernatants, serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CA12

Uniprot ID :

O43570

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A25-A354

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

carbonic anhydrase 12

Synonyms :

Carbonic anhydrase 12; Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3; CA12

Protein Function :

Reversible hydration of carbon dioxide.

Subcellular Localization :

Membrane, Single-pass type I membrane protein

Tissue Specificity :

Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.

Background :

Carbonic anhydrase 12 is an enzyme that in humans is encoded by the CA12 gene. It is mapped to 15q22.2. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene.

Research Category :

Cancer, Tumor Biomarkers