Human CA4/Carbonic anhydrase 4 ELISA Kit PicoKine® | Boster EK1939 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CA4/Carbonic anhydrase 4 ELISA Kit PicoKine®

catalog :

EK1939

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1939

Product Name :

Human CA4/Carbonic anhydrase 4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CA4 ELISA Kit PicoKine® (96 Tests). Quantitate Human CA4 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CA4

Uniprot ID :

P22748

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A19-S284

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

carbonic anhydrase 4

Synonyms :

Carbonic anhydrase 4; Carbonate dehydratase IV; Carbonic anhydrase IV; CA-IV

Protein Function :

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.

Subcellular Localization :

Cell membrane, GPI-anchor

Tissue Specificity :

Expressed in the endothelium of the choriocapillaris in eyes. Not expressed in the retinal epithelium at detectable levels.

Background :

Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene. It is mapped to 17q23.1. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositolanchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport.