Human CLEC1B ELISA Kit PicoKine® | Boster EK1921 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CLEC1B ELISA Kit PicoKine®

catalog :

EK1921

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1921

Product Name :

Human CLEC1B ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CLEC1B ELISA Kit PicoKine® (96 Tests). Quantitate Human CLEC1B in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CLEC1B

Uniprot ID :

Q9P126

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S55-P229

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-type lectin domain family 1 member B

Synonyms :

C-type lectin domain family 1 member B; C-type lectin-like receptor 2; CLEC-2; CLEC1B; CLEC2; UNQ721; PRO1384

Protein Function :

C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

Subcellular Localization :

Membrane. Single-pass type II membrane protein.

Tissue Specificity :

Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.

Background :

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene. This gene is mapped to 12p13.31-p13.2. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.

Research Category :

Immunology, Nk Cells, Non-Cd, T Cells