Rat GAS6 ELISA Kit PicoKine® | Boster EK1915 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat GAS6 ELISA Kit PicoKine®

catalog :

EK1915

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1915

Product Name :

Rat GAS6 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat GAS6 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Gas6 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

Gas6

Uniprot ID :

Q63772

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D115-P673

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

growth arrest specific 6

Synonyms :

Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand; Growth-potentiating factor; GPF; Gas6

Protein Function :

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

Subcellular Localization :

Secreted.

Tissue Specificity :

Plasma

Background :

GAS6 (Growth arrest-specific 6), also known as AXLLG or AXSF, is a human gene coding for the Gas6 protein. It is mapped to 13q34. GAS6 was originally found as a gene upregulated by growth arrested fibroblasts. This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein which thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. What's more, the product of the GAS6 gene, a ligand for the AXL, MER, and TYRO3 tyrosine kinase receptors, is a vitamin K-dependent protein, structurally related to anticoagulant protein S but lacking its anticoagulant activity. This protein also shows great importance in the cardiovascular system.

Research Category :

Atherosclerosis, Cardiovascular, Hematopoietic Progenitors, Mesenchymal Stem Cells, Myeloid, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Stem Cells, Tyrosine Kinases