Human P4HB ELISA Kit PicoKine® | Boster EK1890 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human P4HB ELISA Kit PicoKine®

catalog :

EK1890

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1890

Product Name :

Human P4HB ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human P4HB ELISA Kit PicoKine® (96 Tests). Quantitate Human P4HB in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

P4HB

Uniprot ID :

P07237

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D18-L508

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.8 pg/ml - 6,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

prolyl 4-hydroxylase subunit beta

Synonyms :

Protein disulfide-isomerase; PDI; Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55; P4HB; ERBA2L; PDI; PDIA1; PO4DB

Protein Function :

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modificatio

Subcellular Localization :

Endoplasmic reticulum, Endoplasmic reticulum lumen, Cell membrane, Peripheral membrane protein, Melanosome

Background :

P4HB is a multifunctional and highly abundant enzyme that is part of the protein disulfide isomerase family. It is mapped to 17q25.3. When present as a tetramer consisting of two alpha and two beta subunits, P4HB has a role in hydroxylation of prolyl residues in preprocollagen. P4HB is a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds.

Research Category :

Metabolism, Metabolism Of Lipids And Lipoproteins, Pathways And Processes, Protein Trafficking, Signal Transduction