Human CPE/Carboxypeptidase E ELISA Kit PicoKine® | Boster EK1887 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CPE/Carboxypeptidase E ELISA Kit PicoKine®

catalog :

EK1887

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1887

Product Name :

Human CPE/Carboxypeptidase E ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CPE ELISA Kit PicoKine® (96 Tests). Quantitate Human CPE in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CPE

Uniprot ID :

P16870

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L43-F476

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

carboxypeptidase E

Synonyms :

Carboxypeptidase E; CPE; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase

Protein Function :

Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

Subcellular Localization :

Secreted, secretory vesicle membrane, Peripheral membrane protein, Nucleus

Tissue Specificity :

Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.

Background :

This gene encodes a member of the M14 family of metallocarboxypeptidases. It is mapped to 4q32.3. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes.

Research Category :

Cell Type Marker, Neuron Marker, Neuroscience, Synapse Marker