Human RET ELISA Kit PicoKine® | Boster EK1877 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human RET ELISA Kit PicoKine®

catalog :

EK1877

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1877

Product Name :

Human RET ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human RET ELISA Kit PicoKine® (96 Tests). Quantitate Human RET in cell culture supernatants, serum and plasma (heparin). Sensitivity: 15pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

RET

Uniprot ID :

P07949

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L29-R635

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.8 pg/ml - 6,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

ret proto-oncogene

Synonyms :

Proto-oncogene tyrosine-protein kinase receptor Ret; Cadherin family member 12; Proto-oncogene c-Ret; RET; CDHF12; CDHR16; PTC; RET51

Protein Function :

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates P

Subcellular Localization :

Endosome membrane, Single-pass type I membrane protein, Cell membrane,

Background :

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. It is mapped to 10q11.21. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.

Research Category :

Cancer, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tyrosine Kinases