Human EDAR ELISA Kit PicoKine® | Boster EK1851 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human EDAR ELISA Kit PicoKine®

catalog :

EK1851

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1851

Product Name :

Human EDAR ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human EDAR ELISA Kit PicoKine® (96 Tests). Quantitate Human EDAR in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

EDAR

Uniprot ID :

Q9UNE0

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: E27-A187

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

ectodysplasin A receptor

Synonyms :

Tumor necrosis factor receptor superfamily member EDAR; Anhidrotic ectodysplasin receptor 1; Downless homolog; EDA-A1 receptor; Ectodermal dysplasia receptor; Ectodysplasin-A receptor; EDAR; DL

Protein Function :

Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.

Subcellular Localization :

Membrane. Single-pass type I membrane protein.

Tissue Specificity :

Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.

Background :

Ectodysplasin A receptor (EDAR) is a protein that in humans is encoded by the EDAR gene. It is mapped to 2q13. This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.