Human CES2 ELISA Kit PicoKine® | Boster EK1814 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CES2 ELISA Kit PicoKine®

catalog :

EK1814

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1814

Product Name :

Human CES2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CES2 ELISA Kit PicoKine® (96 Tests). Quantitate Human CES2 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate ). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CES2

Uniprot ID :

O00748

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q27-L559

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

carboxylesterase 2

Synonyms :

Cocaine esterase; Carboxylesterase 2; CE-2; hCE-2; Methylumbelliferyl-acetate deacetylase 2; CES2; ICE

Protein Function :

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.

Subcellular Localization :

Endoplasmic reticulum lumen

Tissue Specificity :

Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.

Background :

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. This gene is mapped to 16q22.1. It encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.

Research Category :

Drug Metabolism, Lipid Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Signal Transduction