Human CES1 ELISA Kit PicoKine® | Boster EK1813 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CES1 ELISA Kit PicoKine®

catalog :

EK1813

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1813

Product Name :

Human CES1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CES1 ELISA Kit PicoKine® (96 Tests). Quantitate Human CES1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 0.1ng/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CES1

Uniprot ID :

P23141

Immunogen :

Expression system for standard: NS0; Immunogen sequence: G18-L567

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<0.1 ng/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

carboxylesterase 1

Synonyms :

Liver carboxylesterase 1; cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1; CE-1; hCE-1; Cocaine carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-acetate deacetylase 1; Monocyte/macrophage serine esterase; Retinyl ester

Protein Function :

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine

Subcellular Localization :

Endoplasmic reticulum lumen

Tissue Specificity :

Expressed predominantly in liver with lower levels in heart and lung.

Background :

Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene. This gene is mapped to 16q12.2. It encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

Research Category :

Cardiovascular, Cholesterol Metabolism, Drug Metabolism, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Lipids / Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Signal Transduction