Human BMP-10 ELISA Kit PicoKine® | Boster EK1808 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human BMP-10 ELISA Kit PicoKine®

catalog :

EK1808

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1808

Product Name :

Human BMP-10 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human BMP-10 ELISA Kit PicoKine® (96 Tests). Quantitate Human BMP10 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate ). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

BMP10

Uniprot ID :

O95393

Immunogen :

Expression system for standard: NS0; Immunogen sequence: N314-R421

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

bone morphogenetic protein 10

Synonyms :

Bone morphogenetic protein 10; BMP-10; BMP10

Protein Function :

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and N

Subcellular Localization :

Secreted

Tissue Specificity :

Detected in mammary epithelia (at protein level).

Background :

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. This gene is mapped to 2p13.3. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.

Research Category :

Cardiogenesis, Cardiovascular, Growth Factors/Hormones, Hypertrophy, Signal Transduction, Transcription Factors/Regulators