Human Endorepellin/HSPG2 ELISA Kit PicoKine® | Boster EK1760 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Endorepellin/HSPG2 ELISA Kit PicoKine®

catalog :

EK1760

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1760

Product Name :

Human Endorepellin/HSPG2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Endorepellin/HSPG2 ELISA Kit PicoKine® (96 Tests). Quantitate Human HSPG2 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate ). Sensitivity: 0.05ng/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

HSPG2

Uniprot ID :

P98160

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E3687-S4391

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.624 ng/ml - 40 ng/ml

Sensitivity :

<0.05 ng/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A polyclonal antibody from goat, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

heparan sulfate proteoglycan 2

Synonyms :

Basement membrane-specific heparan sulfate proteoglycan core protein; HSPG; Perlecan; PLC; HSPG2

Protein Function :

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachm

Subcellular Localization :

basement membrane

Tissue Specificity :

Found in the basement membranes.

Background :

Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

Research Category :

Angiogenesis, Cancer, Cancer Metabolism, Cardiovascular, Cytoskeleton / Ecm, Extracellular Matrix, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Lipids And Lipoproteins, Pathways And Processes, Signal Transduction