Human Ki67 ELISA Kit PicoKine® | Boster EK1759 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Ki67 ELISA Kit PicoKine®

catalog :

EK1759

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1759

Product Name :

Human Ki67 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Ki67 ELISA Kit PicoKine® (96 Tests). Quantitate Human MKI67 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate ). Sensitivity: 1pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

MKI67

Uniprot ID :

P46013

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: N3120-I3256

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

7.8 pg/ml - 500 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

marker of proliferation Ki-67

Synonyms :

Proliferation marker protein Ki-67; Antigen identified by monoclonal antibody Ki-67; Antigen KI-67; Antigen Ki67; MKI67

Protein Function :

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome su

Subcellular Localization :

Nucleus , nucleolus, Chromosome

Tissue Specificity :

Expression occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected (at protein level). Present at highest level in G2 phase and during mitosis (at protein level). In interphase,

Background :

Ki-67 (Proliferation-related Ki-67 antigen), also known as MKI67 or KIA, is a protein that in humans is encoded by the MKI67 gene. This gene is mapped to 10q26.2. From study of a panel of human-rodent somatic cell hybrids, it has been demonstrated that a gene involved in the expression of the MKI67 antigen is located on chromosome 10. By in situ hybridization, Fonatsch et al. (1991) regionalized the MKI67 gene to chromosome 10q25-qter. By FISH, Traut et al. Antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore it is associated with ribosomal RNA transcription. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis.

Research Category :

Tumor Biomarkers