Human Annexin A1 ELISA Kit PicoKine® | Boster EK1745 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Annexin A1 ELISA Kit PicoKine®

catalog :

EK1745

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1745

Product Name :

Human Annexin A1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Annexin A1 ELISA Kit PicoKine® (96 Tests). Quantitate Human ANXA1 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate ). Sensitivity: 100pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ANXA1

Uniprot ID :

P04083

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A2-N346

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<100 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

annexin A1

Synonyms :

Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35; ANXA1; ANX1; LPC1

Protein Function :

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of t

Tissue Specificity :

Detected in resting neutrophils. Detected in peripheral blood T-cells. Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors. Detected in placenta (at protein level). Detected

Background :

ANXA1, also known as lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. ANXA1 belongs to a family of Ca (2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca (2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.

Research Category :

Calcium Signaling, Cell Adhesion, Cytoskeleton / Ecm, Lipid Signaling, Signal Transduction, Signaling Pathway